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Issue 24, 2019
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A comparative study of microporous polyolefin silica-based paper and cellulose paper substrates utilizing paper spray-mass spectrometry in drug analysis

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Abstract

This comparative study proposes an efficient technique by employing a synthetic substrate, which is commercially available, for direct, sensitive, efficient and fast analysis in Paper Spray Mass Spectrometry (PS-MS). The Teslin® substrate is a well-known synthetic paper used in the printing industry, and it is made with a single-layered, microporous polyolefin–silica matrix. Currently, filter paper is one of the most commonly used natural cellulose fiber-based substrates in PS-MS. In this study, the analytical performance of Teslin® vs. filter paper was determined by measuring different physical characteristics such as porosity, solvent elution efficiency and sensitivity of both substrates. The key result of electrostatic-spray ionization in the hydrophobic Teslin® substrate was more efficient detection and direct analysis of a smaller amount of drug samples (1 μL) with an improved signal sensitivity of 26.94-fold in comparison to filter paper. It has been demonstrated that the efficiency of reproducibility of the analyte, signal-noise ratio, and constant longer active signal (>2 min) were notably improved with the hydrophobicity of Teslin® paper by eliminating chromatographic effects. The limit of detection for drug analysis was reported to be in the lower μg mL−1 range.

Graphical abstract: A comparative study of microporous polyolefin silica-based paper and cellulose paper substrates utilizing paper spray-mass spectrometry in drug analysis

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Article information


Submitted
27 Mar 2019
Accepted
19 May 2019
First published
22 May 2019

Anal. Methods, 2019,11, 3066-3072
Article type
Paper

A comparative study of microporous polyolefin silica-based paper and cellulose paper substrates utilizing paper spray-mass spectrometry in drug analysis

Imesha W. De Silva, D. T. Converse, L. A. Juel and G. F. Verbeck, Anal. Methods, 2019, 11, 3066
DOI: 10.1039/C9AY00641A

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