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Issue 20, 2019
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A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection

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Abstract

A catalytic DNA circuit was ingeniously engineered to harness the cleavage of a nicking endonuclease on a triple-stranded duplex DNA probe, autonomously actuating a successive enzyme-powered DNA machine for one-step, isothermal, and autocatalytic nucleic acid analysis. The detection performance could be tuned with or without the use of enzymes.

Graphical abstract: A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection

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Supplementary files

Article information


Submitted
14 Aug 2019
Accepted
08 Sep 2019
First published
09 Sep 2019

Analyst, 2019,144, 5923-5927
Article type
Communication

A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection

S. Liu, C. Xin, X. Yu, Z. Ding and S. Liu, Analyst, 2019, 144, 5923
DOI: 10.1039/C9AN01568J

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