A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection

Shuang Liu; Chen Xin; Xiaoxiao Yu; Zhenbo Ding; Shufeng Liu

doi:10.1039/C9AN01568J

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A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection†

Shuang Liu,^a Chen Xin,^a Xiaoxiao Yu,^a Zhenbo Ding^a and Shufeng Liu

*^a

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* Corresponding authors

^a Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao 266042, China
E-mail: sliu@qust.edu.cn
Fax: +86-532-8402-2681
Tel: +86-532-8402-2681

Abstract

A catalytic DNA circuit was ingeniously engineered to harness the cleavage of a nicking endonuclease on a triple-stranded duplex DNA probe, autonomously actuating a successive enzyme-powered DNA machine for one-step, isothermal, and autocatalytic nucleic acid analysis. The detection performance could be tuned with or without the use of enzymes.

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Article information

DOI: https://doi.org/10.1039/C9AN01568J
Article type: Communication
Submitted: 14 Aug 2019
Accepted: 08 Sep 2019
First published: 09 Sep 2019

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Analyst, 2019,144, 5923-5927

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A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection

S. Liu, C. Xin, X. Yu, Z. Ding and S. Liu, Analyst, 2019, 144, 5923 DOI: 10.1039/C9AN01568J

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A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection†

Abstract

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A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection

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