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Facile fabrication of fluorescent Fe-doped carbon quantum dots for dopamine sensing and bioimaging application

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Abstract

In this paper, we have presented a novel strategy to fabricate Fe-doped carbon quantum dots (Fe-CQDs) for dopamine sensing applications. The Fe-CQDs are obtained by one step hydrothermal carbonization, using ethylenediamine tetraacetic acid salts and ferric nitrate as the carbon and iron source, which simultaneously incorporates Fe (dopamine-bonding site) and luminescent carbon quantum dots (fluorophores). The added dopamine containing catechol groups might form complexes with Fe ions (doped in CQDs) due to coordination. Subsequently, dopamine was oxidized to generate dopamine-quinone (a known potent electron acceptor) species by ambient O2. Thus, the coordination induced dopamine in proximity to the CQDs, which provided favourable electron acceptors in close proximity to the CQDs and produced high quenching efficiencies. Such fluorescence responses can be used for well quantifying dopamine in the range of 0.01–50 μM with a detection limit of 5 nM (S/N = 3). The proposed sensing system has been successfully used for the assay of dopamine in human urine samples. Preliminary cell image study indicates that the obtained Fe-CQDs possess high photostability and low cytotoxicity, which make them promising for biological applications.

Graphical abstract: Facile fabrication of fluorescent Fe-doped carbon quantum dots for dopamine sensing and bioimaging application

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Publication details

The article was received on 09 Sep 2018, accepted on 09 Nov 2018 and first published on 12 Nov 2018


Article type: Paper
DOI: 10.1039/C8AN01741G
Citation: Analyst, 2019, Advance Article
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    Facile fabrication of fluorescent Fe-doped carbon quantum dots for dopamine sensing and bioimaging application

    S. Zhuo, Y. Guan, H. Li, J. Fang, P. Zhang, J. Du and C. Zhu, Analyst, 2019, Advance Article , DOI: 10.1039/C8AN01741G

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