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Issue 34, 2018
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Robust clicked assembly based on iron oxide nanoparticles for a new type of SPR biosensor

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Abstract

We present a novel strategy to create an original nanostructured SPR biosensor with enhanced sensitivity. Our approach consists of using high refractive index dielectric materials to increase the sensitivity factor of a gold thin film despite its large evanescent electromagnetic field decay lengths. Iron oxide nanoparticles were grafted onto a gold thin film and were easily functionalized by biomolecular receptors through a two step copper catalyzed alkyne–azide cycloaddition (CuAAC) “click” reaction. This strategy allowed us to prepare a highly stable and robust nanostructured biosensor. We selected the very-well known biotin–streptavidin couple to demonstrate the efficiency of our strategy toward the enhancement of the detection of biomolecules without using any labelling of the target molecules. High refractive index nanoparticles were demonstrated to enhance markedly the sensitivity to the detection of streptavidin by increasing the sensitivity factor of the gold thin film and the accessibility of biotin groups (reduction of steric hindrance).

Graphical abstract: Robust clicked assembly based on iron oxide nanoparticles for a new type of SPR biosensor

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Publication details

The article was received on 09 Mar 2018, accepted on 20 Jun 2018 and first published on 22 Jun 2018


Article type: Paper
DOI: 10.1039/C8TC01166D
J. Mater. Chem. C, 2018,6, 9102-9110

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    Robust clicked assembly based on iron oxide nanoparticles for a new type of SPR biosensor

    M. Dolci, J. Bryche, C. Leuvrey, S. Zafeiratos, S. Gree, S. Begin-Colin, G. Barbillon and B. P. Pichon, J. Mater. Chem. C, 2018, 6, 9102
    DOI: 10.1039/C8TC01166D

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