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Lithium-containing biomaterials inhibiting osteoclastogenesis of macrophages in vitro and osteolysis in vivo

Abstract

Osteolysis caused by aging, neoplasia, infection, or trauma is a kind of the intractable systemic or local syndrome of bone destruction like peri-implant osteolysis (PIO). The activation of osteoclasts differentiated from macrophages plays a decisive role in such diseases. To conquer this challenge, a biomaterial that is able to inhibit osteoclastogenesis and osteolysis is designed. Recent research shows that lithium (Li) can inhibit pro-inflammatory cytokine release in vitro via its effect on pharmacotherapy of psychiatric illnesses. Therefore, we synthesized a pure-phase lithium-calcium-silicate (Li2Ca2Si2O7, LCS) bioceramic and further prepared the extracts to assess the effect of LCS on RANKL-induced osteoclastogenesis in vitro and Ti particles-induced osteolysis in vivo as well as the corresponding mechanism. The resutls demonstrated that LCS inhibited RANKL-induced osteoclastogenesis of macrophages, bone resorption area, and F-actin ring formation in a dose-dependent manner. The mechanism is related to the suppression of NF-kB signaling pathways mediating the inhibitory effects of LCS. Moreover, LCS was found to be able to inhibit the calvarial osteolysis in mouse model through micro-CT and histological analysis. These findings suggest that LCS may be a promising biomaterial for suppressing the osteolysis, paving the way for treating osteoporosis by using bioactive inorganic materials.

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Publication details

The article was received on 11 Oct 2018, accepted on 05 Nov 2018 and first published on 07 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB02678E
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Lithium-containing biomaterials inhibiting osteoclastogenesis of macrophages in vitro and osteolysis in vivo

    C. Pan, L. Chen, R. Wu, H. Shan, Z. Zhou, Y. Lin, X. Yu, L. Yan and C. Wu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02678E

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