Jump to main content
Jump to site search


Carboplatin prodrug conjugated Fe3O4 nanoparticles for magnetically targeted drug delivery in ovarian cancer cells

Abstract

Platinum (Pt)-based drugs including cisplatin, carboplatin and oxaliplatin have been widely used as first-line anticancer regimens due to their excellent anticancer efficacy. However, the clinical application of these drugs is greatly limited due to the side effects and drug resistance. In this study, an antitumor drug delivery system based on carboplatin prodrug loading Fe3O4 nanoparticles (NPs@Carboplatin) was developed and the antitumor activity was also investigated. The as-synthesized NPs@Carboplatin has an average diameter of 7.88 mm with a zeta potential of 8.11 mV. It exhibited higher cytotoxic effect than carboplatin on both A2780 (cisplatin sensitive) and A2780DDP (cisplatin resistant) ovarian cancer cells via MTT assay, which can overcome Pt resistance. Moreover, the nanoparticles (NPs) loaded with carboplatin possess excellent delivery capability, which can be effectively taken up by ovarian cancer cell lines through endocytosis process. With excellent delivery capability as carriers, NPs@Carboplatin can promote drug internalization and result in the increase of intracellular drug accumulation with enhanced cellular cytotoxicity. Furthermore, in vivo experiments demonstrated that NPs@Carboplatin can widely distribute into major organs, in the presence of external magnetic field, the Fe3O4 nanocarrier is beneficial to visualize the tumor site location and promote the subsequent antitumor efficacy. It revealed relatively high tumor inhibition rate without obvious potential toxicity on normal organs. Taken together, these results indicate that the magnetically targeted NPs@Carboplatin can act as a drug delivery system and will have great potential in ovarian cancer therapeutic applications.

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Sep 2018, accepted on 21 Nov 2018 and first published on 30 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB02574F
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
  •   Request permissions

    Carboplatin prodrug conjugated Fe3O4 nanoparticles for magnetically targeted drug delivery in ovarian cancer cells

    H. Song, F. Quan, Z. Yu, M. Zheng, Y. Ma, H. Xiao and F. Ding, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02574F

Search articles by author

Spotlight

Advertisements