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Carbon-mediated synthesis of shape-controllable manganese phosphate as Nanozyme for modulation of superoxide anions in Hela cells

Abstract

Transition metal phosphate has shown great potential as Nanozyme for selective detection of reactive oxygen species (ROS) but its application was hindered by the complicated synthesis and difficulty in shape and size control. Here we present a facile method to fabricate transition metal phosphate by using hollow carbon structures as substrates. Manganese phosphate is a typical Nanozyme used in this design and the shape and size of Mnx(PO4)y layer can be efficiently controlled by altering carbon substrates. Characterizations demonstrated that Mnx(PO4)y layer modified hollow carbon sphere (Mn-MPSA-HCS) and hollow carbon cubic (Mn-MPSA-HCC) were successfully prepared and used as Nanozyme for superoxide detection. The established electrochemical sensor was employed in the online monitoring of drug stimulated superoxide anions released from cancer cells. This method can be adapted as a general way to prepare transition metal phosphate layer with various controllable shapes and sizes as Nanozyme for different uses in the future.

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Publication details

The article was received on 30 Sep 2018, accepted on 27 Nov 2018 and first published on 29 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB02573H
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Carbon-mediated synthesis of shape-controllable manganese phosphate as Nanozyme for modulation of superoxide anions in Hela cells

    X. Cai, Z. Wang, H. Zhang, Y. Li, K. Chen, H. Zhao and M. LAN, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02573H

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