Jump to main content
Jump to site search


Light-responsive Multifunctional Nanoplatform for Photochemical Internalization Mediated Resistance–Free Photodynamic Therapy

Abstract

Photodynamic therapy (PDT) has been widely used as a noninvasive and moderate technique in precision cancer therapy by destroying cancer cells via light induced reactive oxygen species (ROS). However, the overproduction of heat shock protein 70 (HSP70) induced by ROS will contribute to the cell survival in harsh conditions, finally leading to decreased PDT efficiency. To overcome this issue, herein, for the first time, we prepare HSP70 inhibitor (2–phenylethynesulfonamide (PES)) loaded graphitic carbon nitride nanosheet (GCNS) as a multifunctional nanoplatform (GCNS–PES) for resistance–free PDT. By taking advantage of commendable PDT efficiency, strong blue fluorescence, satisfactory drug loading capacity and good water dispersity, GCNS can simultaneously serve as a photosensitizer, an imaging agent and a drug carrier. Moreover, when the nanoplatform is restricted in the endo/lysosome vesicles through endocytosis, GCNS can generate ROS effectively under visible light irradiation to promote the lipid peroxidation of endo/lysosomal membranes and accelerate the liberation of GCNS and PES into cytoplasm. Finally, the tolerance of cancer cells to ROS is decreased by PES induced HSP70 inactivation, therefore the efficiency of PDT is significantly enhanced. As a result, GCNS–PES can serve as a promising therapeutic nanoplatform in photo–controlled cancer therapy.

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Sep 2018, accepted on 30 Oct 2018 and first published on 31 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB02535E
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
  •   Request permissions

    Light-responsive Multifunctional Nanoplatform for Photochemical Internalization Mediated Resistance–Free Photodynamic Therapy

    C. Liu, H. Qin, L. Kang, Z. Chen, H. Wang, H. Qiu, J. Ren and X. Qu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02535E

Search articles by author

Spotlight

Advertisements