Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

Koushambi Mitra; Montserrat Samsó; Charles E. Lyons; Matthew C. T. Hartman

doi:10.1039/C8TB02533A

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Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light†

Koushambi Mitra,

^ab Montserrat Samsó,^c Charles E. Lyons^b and Matthew C. T. Hartman

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA
E-mail: mchartman@vcu.edu

^b Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA

^c Department of Physiology and Biophysics, 1101 E. Marshall St., Richmond, VA 23298, USA

Abstract

Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc–Pt–HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc–Pt–HA conjugate showed specific uptake, photo-enhanced cytotoxicity (∼1500 fold) and mitochondrial accumulation in breast cancer over normal cells.

This article is part of the themed collection: International Year of the Periodic Table: Precious metals for cancer treatment

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Article information

DOI: https://doi.org/10.1039/C8TB02533A
Article type: Communication
Submitted: 26 Sep 2018
Accepted: 15 Oct 2018
First published: 24 Oct 2018

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J. Mater. Chem. B, 2018,6, 7373-7377

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Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

K. Mitra, M. Samsó, C. E. Lyons and M. C. T. Hartman, J. Mater. Chem. B, 2018, 6, 7373 DOI: 10.1039/C8TB02533A

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Journal of Materials Chemistry B

Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light†

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Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

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