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Albumin conjugates and assemblies as versatile bio-functional additives and carriers for biomedical applications

Abstract

As the most abundant plasma protein, serum albumin has been extensively studied and employed for therapeutic applications. Despite its direct clinical use for maintenance of blood homeostasis in various medical conditions, this review exclusively summarizes and discusses albumin-based bio-conjugates and assemblies devoted as versatile bio-functional additives and carriers to biomedical applications. As one of the smallest-sized proteins in human body, albumin is physiochemically stable and biochemically inert. Moreover, albumin is also endowed with abundant specific binding sites to numerous therapeutic compounds, which renders it superior bioactivities as well. First of all, due to its small size and binding specificity, albumin per se or derived assemblies can be utilized as competent drug carriers that can deliver drugs through enhanced permeability and retention (EPR) effect or actively target lesion sites through binding with gp60 and Secreted Protein Acidic and Rich in Cysteine (SPARC) in tumor sites. Furthermore, the biochemical stability and inertness make it a safe and biocompatible coating material for use in biomedical application. Albumin based surface modifying additives can be used to functionalize both macro substrates (e.g. surfaces of medical devices or implants) and nanoparticles surfaces (e.g. drug carriers and imaging contrast agents). In this review, we have elaborated the syntheses and applications of albumin-based bio-functional coatings and drug carriers, respectively.

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Publication details

The article was received on 20 Sep 2018, accepted on 05 Nov 2018 and first published on 06 Nov 2018


Article type: Review Article
DOI: 10.1039/C8TB02477D
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Albumin conjugates and assemblies as versatile bio-functional additives and carriers for biomedical applications

    C. Tao, Y. J. Chuah, C. Xu and D. Wang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02477D

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