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Comparative evaluation of the biocompatible and physical-chemical properties of poly(lactide-co-glycolide) and polydopamine as coating materials for bacterial cellulose

Abstract

The aim of this study was to investigate the influence of poly(lactide-co-glycolide) (PLGA) and polydopamine (PDA) coatings on the tensile strength, surface performance, in vitro cell behavior and in vivo material-tissue reaction of bacterial cellulose (BC) membranes. The coated membranes were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and scanning electron microscopy (SEM), demonstrating that the PDA nanoparticles can penetrate into the BC substrates and that PLGA only adheres to the BC surface. As a result, the PLGA coating decreases the mechanical strength of the BC membrane by phase separating the coating from the substrate, while PDA enhances the mechanical strength by strongly bonding the nanofibers. The in vitro cell culture experiments were established to assess cell attachment and spreading by SEM and DAPI (4',6-diamidino-2-phenylindole) staining, which showed a better performance on the PDA coatings than on the PLGA-coated and bare BC membranes. However, the in vivo results of the rabbit back implantation indicated that BC membrane surface modification by PDA is not effective for cell proliferation and collagen accumulation.

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Publication details

The article was received on 17 Sep 2018, accepted on 30 Nov 2018 and first published on 05 Dec 2018


Article type: Paper
DOI: 10.1039/C8TB02456A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Comparative evaluation of the biocompatible and physical-chemical properties of poly(lactide-co-glycolide) and polydopamine as coating materials for bacterial cellulose

    L. Chen, S. zhang, L. sheng and T. Xi, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02456A

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