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NIR-responsive carbon-based nanocarriers for switchable on/off drug release and synergistic cancer therapy

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Abstract

Herein, we present a light-switchable drug delivery system based on chitosan-gated carbon-based nanocarriers (CGC NCs) that exhibit a loading capacity for doxorubicin as high as ∼89.65 wt% and controlled on/off release with/without NIR irradiation. In vitro and in vivo results show that the CGC NCs manifest high efficacy for cancer therapy through a synergistic effect of combined chemo-photothermal treatment.

Graphical abstract: NIR-responsive carbon-based nanocarriers for switchable on/off drug release and synergistic cancer therapy

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Publication details

The article was received on 11 Sep 2018, accepted on 23 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8TB02398K
Citation: J. Mater. Chem. B, 2018, Advance Article
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    NIR-responsive carbon-based nanocarriers for switchable on/off drug release and synergistic cancer therapy

    R. Nie, H. Liu, L. Hu, X. Gu, J. Qian and H. Wang, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB02398K

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