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Enzymatically crosslinked poly(2-alkyl-2-oxazoline) networks for 3D cell culture

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Abstract

Molecularly designed, random copolymer-bioconjugates based on poly(2-methyl-2-oxazoline) (PMOXA) and poly(2-ethyl-2-oxazoline) (PEOXA) are crosslinked in the presence of sortase A (SA) and human articular chondrocytes (hACs), to yield cellularized polymer networks. Their gelation kinetics and mechanical properties are finely tuned by varying the concentration of SA, while a cell viability >90% is achieved after several weeks of culture, even in the absence of any cell-adhesive cue.

Graphical abstract: Enzymatically crosslinked poly(2-alkyl-2-oxazoline) networks for 3D cell culture

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Publication details

The article was received on 10 Sep 2018, accepted on 20 Oct 2018 and first published on 22 Oct 2018


Article type: Communication
DOI: 10.1039/C8TB02382D
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Enzymatically crosslinked poly(2-alkyl-2-oxazoline) networks for 3D cell culture

    L. Trachsel, N. Broguiere, J. Rosenboom, M. Zenobi-Wong and E. M. Benetti, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB02382D

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