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The conjugates of forky peptides and nonsteroidal anti-inflammatory drugs (NSAID) self-assemble into supramolecular hydrogels for prostate cancer-specific drug delivery.

Abstract

Here we report supramolecular hydrogelators made of forky peptides and nonsteroidal anti-inflammatory drugs (NSAID). Two zinc ions (ZIs)-responsive short peptide dendrons (E3FID and E3FNP) modified by NSAID ( indometacin and naproxen) were designed and synthesized successfully, these novel small molecule hydrogelators can self-assemble in water to form stable supramolecular nanofibers/hydrogels. The formation of these supramolecular hydrogels can be triggered by zinc ions, which are highly concentrated in prostate tissue. The anticancer drugs docetaxel (DTX) was employed as chemotherapeutics and loaded into the hydrogels to construct a novel drug delivery system for prostate cancer therapy. This approach is anticipated realizing the sustained release of antitumor drugs at the prostate and relieving of cancer pain in the meantime. The E3FID hydrogel and E3FNP hydrogel have excellent biocompatibility and viscoelastic properties as the promising drugs delivery material. The results of drugs release in vitro indicated that DTX was released slowly following a non-Fickian diffusion mechanism. In addition, the results of cytotoxicity assay in vitro demonstrated that these DTX-loaded hydrogels exhibited dose-dependent cytotoxicity to both DU-145 cells and PC-3 cells, especially the drug-loaded hydrogel of E3FID had better anticancer efficacy obviously. As a drug delivery strategy, the system realizes better anticancer efficacy, excellent sustained-release and soothing of cancer pain simultaneously, the most important being that the DDS facilitate local delivery of drug to the prostate.

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Publication details

The article was received on 02 Sep 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8TB02307G
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    The conjugates of forky peptides and nonsteroidal anti-inflammatory drugs (NSAID) self-assemble into supramolecular hydrogels for prostate cancer-specific drug delivery.

    M. Tao, S. He, J. Liu, H. Li, L. Mei, C. Wu, K. Xu and W. Zhong, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02307G

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