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Platelets and their biomimetics for regenerative medicine and cancer therapies

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Abstract

Platelets, circulating blood cells derived from megakaryocytes, play a key role in various physical activities, including coagulation, hemostasis, the body's innate immune response, and cancer metastasis. By taking advantage of their key traits, researchers have developed strategies to exploit platelets and platelet-mimicking nanoassemblies to treat a number of conditions, including wounds, cancers, and bacterial infections. Compared to traditional polymer, liposome, and inorganic nanoparticle-based delivery systems, platelets and platelet-mimicking vehicles hold many advantages. Among these are their enhanced circulation time, their large volumes and surface areas for drug loading or conjugation, and their inherent ability to target some diseases. In this review, we will highlight the recent progress made in the development of disease-targeting platelets and platelet-mimicking vehicles as therapeutic platforms.

Graphical abstract: Platelets and their biomimetics for regenerative medicine and cancer therapies

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Publication details

The article was received on 31 Aug 2018, accepted on 22 Oct 2018 and first published on 22 Oct 2018


Article type: Review Article
DOI: 10.1039/C8TB02301H
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Platelets and their biomimetics for regenerative medicine and cancer therapies

    Z. Li, S. Hu and K. Cheng, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB02301H

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