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Sequential delivery of bismuth nanoparticles and doxorubicin by injectable macroporous hydrogel for combined anticancer kilovoltage X-ray radio- and chemo-therapy

Abstract

Sequential delivery systems are required to maximize synergistic anticancer therapeutic effect in combined X-ray radio- and chemo-therapy. Here, we described an injectable macroporous hydrogel as a sequential delivery platform for combined kilovoltage X-ray radio- and chemo- therapy of 4T1 breast cancer. The macroporous hydrogel offered two sequentially distinct delivery profiles for co-loaded radiosensitizers (bismuth nanoparticles, Bi NPs) and anticancer drug (doxorubicin, DOX). Bi NPs was released preferentially and completely during 24 h; however, DOX was released slowly in the first 24 h and was released sustainedly during one week. This sequential release behavior of Bi NPs and DOX in macroporous hydrogel achieved significantly synergistic antitumor effects in vitro. In vivo studies further indicated that this macroporous hydrogel interacted with kilovoltage X-ray radiation could effectively inhibit tumor growth and dramatically improve the survival ratio in mice to 100%. Furthermore, the released Bi NPs from macroporous hydrogel could be dissolved and discharged from body as soluble bismuth ions after treatment. These results suggested that the injectable macroporous hydrogel may serve as combinational therapeutic platform for clinical superficial cancer therapy.

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Publication details

The article was received on 30 Aug 2018, accepted on 01 Nov 2018 and first published on 05 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB02284D
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Sequential delivery of bismuth nanoparticles and doxorubicin by injectable macroporous hydrogel for combined anticancer kilovoltage X-ray radio- and chemo-therapy

    J. Deng, X. Xun, W. Jun, Y. Su, L. Zheng, C. Wang and M. Su, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02284D

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