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Quantum dots tethered membrane type 3 matrix metalloproteinase-targeting peptide for tumor optical imaging

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Abstract

Membrane type matrix metalloproteinases (MT-MMPs) play important roles in malignant tumor progression through the degradation of the extracellular matrix and signal transduction. However, a member of the family, MT3-MMP, has attracted the least concern compared with other MT-MMPs. Here, a novel MT3-MMP-targeting peptide with high affinity and specificity has been developed by a phage-display peptide screening technology and multiple biophysics measurements, including single-molecule recognition force spectroscopy and isothermal titration calorimetry. The binding peptides are conjugated on the surface of CdSe/ZnS quantum dots (QDs) and consequently acted as a ligand that specifically targets MT3-MMP overexpressed tumor cells. The imaging nanoprobes used QDs as the photographic developer for optical imaging in vivo. The nanoprobes exhibited a desirable targeting effect and generated good biodistribution profiles for visualization and imaging of MT3-MMP overexpressed tumor. The peptide could be useful to evaluate the distribution and expression of MT3-MMP. Furthermore, the peptide-functionalized QDs show potential application for cancer diagnosis.

Graphical abstract: Quantum dots tethered membrane type 3 matrix metalloproteinase-targeting peptide for tumor optical imaging

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Publication details

The article was received on 02 Aug 2018, accepted on 21 Sep 2018 and first published on 26 Sep 2018


Article type: Paper
DOI: 10.1039/C8TB02025F
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Quantum dots tethered membrane type 3 matrix metalloproteinase-targeting peptide for tumor optical imaging

    L. Ren, Q. Li, Z. Ma, Y. Wang, H. Li, L. Shen, J. Yu and X. Fang, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB02025F

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