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A DOPA-Functionalized Chondroitin Sulfate-Based Adhesive Hydrogel as a Promising Multi-functional Bioadhesive

Abstract

Great progress has been achieved on the studies of hydrogel, which was presented for the first time in 1960 by Otto Wichterle and Drahoslav Lím. The two crucial properties of hydrogels, namely high-water content and biocompatibility have made hydrogels ideal compositions in the development of bioadhesives in recent years. Chondroitin sulfate (CS), a sulfated Glycosaminoglycan (GAG), is distributed throughout animal bodies including cartilages and extracellular matrix (ECM), and it has been widely utilized in dietary supplemental and pharmaceutical industries. Besides, CS has been reported excellent pain-relief and anti-inflammation properties. Some studies have even reported CS’s wound healing promoting ability. In this study, taking the advantages of CS’s excellent physical and chemical properties, DOPA groups were functionalized onto CS backbones. After that, the potentials of the newly established CS-DOPA (CSD) hydrogel to work as a bioadhesive in multiple internal medications have been evaluated through in vitro and in vivo means. The outcomes of the in vivo assessments have demonstrated CSD’s promising potential to be further commercialized into an adhesive hydrogel product, and to be utilized in diverse clinical medications in the future.

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Publication details

The article was received on 31 Jul 2018, accepted on 30 Nov 2018 and first published on 08 Dec 2018


Article type: Paper
DOI: 10.1039/C8TB01990H
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    A DOPA-Functionalized Chondroitin Sulfate-Based Adhesive Hydrogel as a Promising Multi-functional Bioadhesive

    W. Zhu, J. Iqbal and D. Wang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01990H

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