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Issue 33, 2018
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AS1411-decorated niosomes as effective nanocarriers for Ru(iii)-based drugs in anticancer strategies

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Abstract

Niosomes are self-assembled vesicles made up of single chain non-ionic surfactants combined with appropriate amounts of cholesterol or other lipids, exploited as carriers for hydrophilic or lipophilic drugs. Compared to liposomes, niosomes are typically more stable, less expensive and, being generally obtained from synthetic surfactants, more easily derivatizable, providing vesicular structures with a higher versatility and chemical diversity. Herein, we investigated the physico-chemical and biological properties of niosomes loaded with two active ingredients, i.e. the nucleolipidic Ru(III)-complex HoThyRu, selected as an anticancer agent, and the nucleolin-targeting AS1411 aptamer, allowing selective recognition of cancer cells. The morphology, average size, zeta potential, electrophoretic mobility, and stability over time of the functionalized niosomes were analyzed using different biophysical techniques. These formulations, tested on both cancer and normal cells, showed promising antiproliferative activity on HeLa cells, with a higher efficacy associated with the nanosystems containing both AS1411 and HoThyRu with respect to the controls. In all the tested cell lines, AS1411 proved to markedly enhance the bioactivity of the Ru(III)-containing niosomes.

Graphical abstract: AS1411-decorated niosomes as effective nanocarriers for Ru(iii)-based drugs in anticancer strategies

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Supplementary files

Article information


Submitted
14 Jun 2018
Accepted
27 Jul 2018
First published
27 Jul 2018

J. Mater. Chem. B, 2018,6, 5368-5384
Article type
Paper

AS1411-decorated niosomes as effective nanocarriers for Ru(III)-based drugs in anticancer strategies

C. Riccardi, C. Fàbrega, S. Grijalvo, G. Vitiello, G. D’Errico, R. Eritja and D. Montesarchio, J. Mater. Chem. B, 2018, 6, 5368
DOI: 10.1039/C8TB01563E

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