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Issue 47, 2018
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Biosynthetic calcium-doped biosilica with multiple hemostatic properties for hemorrhage control

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Abstract

In this study, we reported calcium-doped biosilica (Ca-biosilica) with multiple hemostatic properties derived from Coscinodiscus sp. frustule. The incorporation of calcium into the diatom frustule was achieved by a simple biosynthetic route through feeding the diatoms with calcium chloride, which was confirmed by calcein staining and EDXS. Ca-Biosilica exhibited an efficient water absorption ratio (36.36 ± 1.44 times its own weight of liquid), superior compatibility (hemolysis ratio <5%, no cytotoxicity against MEFs) and excellent hemostatic effect (203.67 ± 15.63 s at 5 mg mL−1; 145.01 ± 20.41 s at 10 mg mL−1). The intrinsic blood coagulation pathway was clearly strengthened by the unique interface of Ca-biosilica, which was rich in silanol groups and calcium, leading to fast hemorrhage control in rat-tail amputation model. The clotting time of Ca-biosilica was 88.34 ± 28.54 s, which was similar to that of Quickclot® zeolite, whereas only one-third blood loss by weight (0.21 ± 0.16 g) was found in Ca-biosilica-treated group compared with that of the Quickclot® zeolite group (0.63 ± 0.09 g). The results prove that Ca-biosilica is promising as a quick hemostatic agent due to its effectiveness, excellent biocompatibility and simple and environmentally friendly preparation process.

Graphical abstract: Biosynthetic calcium-doped biosilica with multiple hemostatic properties for hemorrhage control

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Publication details

The article was received on 10 Mar 2018, accepted on 06 Nov 2018 and first published on 12 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB00667A
Citation: J. Mater. Chem. B, 2018,6, 7834-7841
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    Biosynthetic calcium-doped biosilica with multiple hemostatic properties for hemorrhage control

    J. Li, J. Han, Q. Sun, Y. Wang, Y. Mu, K. Zhang, X. Dou, M. Kong, X. Chen and C. Feng, J. Mater. Chem. B, 2018, 6, 7834
    DOI: 10.1039/C8TB00667A

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