Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

Roger Honorato Piva; Marina Campos Rocha; Diógenes Honorato Piva; Oscar Rubem Klegues Montedo; Hidetake Imasato; Iran Malavazi; Ubirajara Pereira Rodrigues-Filho

doi:10.1039/C7TB02763J

Combating pathogens with Cs_2.5H_0.5PW₁₂O₄₀ nanoparticles: a new proton-regulated antimicrobial agent†

Roger Honorato Piva,

‡*^a Marina Campos Rocha,‡^b Diógenes Honorato Piva,

^c Oscar Rubem Klegues Montedo,

^d Hidetake Imasato,^a Iran Malavazi^b and Ubirajara Pereira Rodrigues-Filho^a

Author affiliations

* Corresponding authors

^a Grupo de Química de Materiais Híbridos e Inorgânicos, Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos – SP, Brazil
E-mail: honorato.piva@ua.pt

^b Departamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos – SP, Brazil

^c Programa de Pós-Graduação em Ciência e Engenharia de Materiais – PPG-CEM, Universidade Federal de São Carlos, São Carlos – SP, Brazil

^d Grupo de Pesquisa em Cerâmica Técnica – CERTEC, Programa de Pós-Graduação em Ciência e Engenharia de Materiais – PPGCEM, Universidade do Extremo Sul Catarinense, Criciúma – SC, Brazil

Abstract

The transfer of pathogens from contaminated surfaces to patients is one of the main causes of health care-associated infections (HCAIs). Cases of HCAIs due to multidrug-resistant organisms have been growing worldwide, whereas inorganic nano-antimicrobials are valuable today for the prevention and control of HCAIs. Here, we present a cesium salt of phosphotungstic heteropolyacid (Cs_2.5H_0.5PW₁₂O₄₀) as a promising nanomaterial for use in antimicrobial product technologies. This water-insoluble Keggin salt exhibits a broad biocide spectrum against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi even under dark conditions. The Cs_2.5H_0.5PW₁₂O₄₀ nanoparticles (NPs) act as a proton-regulated antimicrobial whose activity is mediated on the release of hydronium ions (H₃O⁺), yielding an in situ acidic pH several units below those tolerable by most of the fungal and bacterial nosocomial pathogens.

This article is part of the themed collection: Materials and Nano Research in Brazil

Supplementary files

Article information

DOI: https://doi.org/10.1039/C7TB02763J
Article type: Paper
Submitted: 20 Oct 2017
Accepted: 01 Dec 2017
First published: 01 Dec 2017

Download Citation

J. Mater. Chem. B, 2018,6, 143-152

Permissions

Request permissions

Combating pathogens with Cs_2.5H_0.5PW₁₂O₄₀ nanoparticles: a new proton-regulated antimicrobial agent

R. H. Piva, M. C. Rocha, D. H. Piva, O. R. K. Montedo, H. Imasato, I. Malavazi and U. P. Rodrigues-Filho, J. Mater. Chem. B, 2018, 6, 143 DOI: 10.1039/C7TB02763J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Journal of Materials Chemistry B