Jump to main content
Jump to site search

Issue 46, 2018
Previous Article Next Article

Influence of protein charge patches on the structure of protein–polyelectrolyte complexes

Author affiliations

Abstract

We employ a combination of the single chain in mean field simulation approach with the solution of Poisson's equation to study the influence of charge heterogeneities on the structure of protein–polyelectrolyte complexes. By adopting a coarse-grained model of representing proteins as charged nanoparticles, we studied the influence of the pattern of charge heterogeneities, net charge, ratio of positive to negative charges on the patches, and the volume fraction of the particles on the structural and aggregation characteristics of proteins in polyelectrolyte solutions. Our results demonstrate that the pattern of charge heterogeneities can exert a significant influence on the resulting characteristics of the aggregates, in some cases leading to a transformation from polymer-bridged complexes into direct particle aggregates driven by the attraction between oppositely charged patches.

Graphical abstract: Influence of protein charge patches on the structure of protein–polyelectrolyte complexes

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Jul 2018, accepted on 29 Oct 2018 and first published on 15 Nov 2018


Article type: Paper
DOI: 10.1039/C8SM01535J
Citation: Soft Matter, 2018,14, 9475-9488
  •   Request permissions

    Influence of protein charge patches on the structure of protein–polyelectrolyte complexes

    R. Samanta and V. Ganesan, Soft Matter, 2018, 14, 9475
    DOI: 10.1039/C8SM01535J

Search articles by author

Spotlight

Advertisements