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Issue 44, 2018
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Adhesion-based sorting of blood cells: an adhesive dynamics simulation study

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Abstract

Blood cells can be sorted in microfluidic devices not only based on their sizes and deformability, but also based on their adhesive properties. In particular, white blood cells have been shown to be sorted out by using adhesive micropatterns made from stripes that are tilted in regard to the direction of shear flow. Here we use adhesive dynamics simulations for round cells to quantitatively investigate this effect and to predict the optimal tilt angle. We then apply our method to predict optimal sorting conditions for malaria-infected red blood cells, which like white blood cells also adhere to and roll on adhesive substrates.

Graphical abstract: Adhesion-based sorting of blood cells: an adhesive dynamics simulation study

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Publication details

The article was received on 26 Jul 2018, accepted on 26 Oct 2018 and first published on 29 Oct 2018


Article type: Paper
DOI: 10.1039/C8SM01524D
Citation: Soft Matter, 2018,14, 9061-9070
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    Adhesion-based sorting of blood cells: an adhesive dynamics simulation study

    A. K. Dasanna and U. S. Schwarz, Soft Matter, 2018, 14, 9061
    DOI: 10.1039/C8SM01524D

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