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Issue 10, 2018
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Reconstitution of composite actin and keratin networks in vesicles

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Abstract

Although cytoskeletal networks are interpenetrating and interacting in living cells, very little is understood as to the effect their interaction has on their properties. Here, as a step towards elucidating the synergistic cellular role of these structural proteins, we investigate isolated keratin and actin composites and show how the in vitro network formation of keratin influences the properties of actin networks and vice versa. By encapsulating purified composite networks into vesicles and separating the time scales of network formation we are able to demonstrate that the actin network stabilizes keratin networks by providing an elastic resistance to their collapse in vitro.

Graphical abstract: Reconstitution of composite actin and keratin networks in vesicles

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Publication details

The article was received on 26 Apr 2017, accepted on 15 Feb 2018 and first published on 21 Feb 2018


Article type: Paper
DOI: 10.1039/C7SM00819H
Soft Matter, 2018,14, 1897-1902

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    Reconstitution of composite actin and keratin networks in vesicles

    J. Deek, R. Maan, E. Loiseau and A. R. Bausch, Soft Matter, 2018, 14, 1897
    DOI: 10.1039/C7SM00819H

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