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Issue 10, 2018
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Reconstitution of composite actin and keratin networks in vesicles

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Abstract

Although cytoskeletal networks are interpenetrating and interacting in living cells, very little is understood as to the effect their interaction has on their properties. Here, as a step towards elucidating the synergistic cellular role of these structural proteins, we investigate isolated keratin and actin composites and show how the in vitro network formation of keratin influences the properties of actin networks and vice versa. By encapsulating purified composite networks into vesicles and separating the time scales of network formation we are able to demonstrate that the actin network stabilizes keratin networks by providing an elastic resistance to their collapse in vitro.

Graphical abstract: Reconstitution of composite actin and keratin networks in vesicles

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Article information


Submitted
26 Apr 2017
Accepted
15 Feb 2018
First published
21 Feb 2018

Soft Matter, 2018,14, 1897-1902
Article type
Paper

Reconstitution of composite actin and keratin networks in vesicles

J. Deek, R. Maan, E. Loiseau and A. R. Bausch, Soft Matter, 2018, 14, 1897
DOI: 10.1039/C7SM00819H

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