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Issue 41, 2018
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A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution

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Abstract

A simple, one-step method for covalent bond immobilization of biomolecules on silica operated in water is described. In the approach, an NHS-ester linked methallylsilane is utilized as a bifunctional linker to couple the biomolecule to the silica surface. Weak organic acid such as acetic acid activates the silica surface enough to react with bifunctional linker without destroying activity of biomolecule.

Graphical abstract: A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution

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Supplementary files

Article information


Submitted
11 Jun 2018
Accepted
23 Aug 2018
First published
24 Aug 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 7981-7985
Article type
Edge Article

A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution

Y. Sim, H. Jung, S. H. Kim, J. Park, W. Park and C. Jun, Chem. Sci., 2018, 9, 7981
DOI: 10.1039/C8SC02565G

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    [Original citation] - Published by The Royal Society of Chemistry.

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