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Issue 28, 2018
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Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet

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Abstract

Laplace NMR (LNMR) offers deep insights on diffusional and rotational motion of molecules. The so-called “ultrafast” approach, based on spatial data encoding, enables one to carry out a multidimensional LNMR experiment in a single scan, providing from 10 to 1000-fold acceleration of the experiment. Here, we demonstrate the feasibility of ultrafast diffusion–T2 relaxation correlation (DT2) measurements with a mobile, low-field, relatively low-cost, single-sided NMR magnet. We show that the method can probe a broad range of diffusion coefficients (at least from 10−8 to 10−12 m2 s−1) and reveal multiple components of fluids in heterogeneous materials. The single-scan approach is demonstrably compatible with nuclear spin hyperpolarization techniques because the time-consuming hyperpolarization process does not need to be repeated. Using dynamic nuclear polarization (DNP), we improved the NMR sensitivity of water molecules by a factor of 105 relative to non-hyperpolarized NMR in the 0.3 T field of the single-sided magnet. This enabled us to acquire a DT2 map in a single, 22 ms scan, despite the low field and relatively low mole fraction (0.003) of hyperpolarized water. Consequently, low-field, hyperpolarized ultrafast LNMR offers significant prospects for advanced, mobile, low-cost and high-sensitivity chemical and medical analysis.

Graphical abstract: Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet

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Publication details

The article was received on 21 Mar 2018, accepted on 27 Jun 2018 and first published on 28 Jun 2018


Article type: Edge Article
DOI: 10.1039/C8SC01329B
Citation: Chem. Sci., 2018,9, 6143-6149
  • Open access: Creative Commons BY license
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    Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet

    J. N. King, A. Fallorina, J. Yu, G. Zhang, V. Telkki, C. Hilty and T. Meldrum, Chem. Sci., 2018, 9, 6143
    DOI: 10.1039/C8SC01329B

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