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Issue 3, 2018

Direct sulfonylation of anilines mediated by visible light

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Sulfones feature prominently in biologically active molecules and are key functional groups for organic synthesis. We report a mild, photoredox-catalyzed reaction for sulfonylation of aniline derivatives with sulfinate salts, and demonstrate the utility of the method by the late-stage functionalization of drugs. Key features of the method are the straightforward generation of sulfonyl radicals from bench-stable sulfinate salts and the use of simple aniline derivatives as convenient readily available coupling partners.

Graphical abstract: Direct sulfonylation of anilines mediated by visible light

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Article information

05 Sep 2017
07 Nov 2017
First published
16 Nov 2017

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 629-633
Article type
Edge Article

Direct sulfonylation of anilines mediated by visible light

T. C. Johnson, Bryony L. Elbert, A. J. M. Farley, T. W. Gorman, C. Genicot, B. Lallemand, P. Pasau, J. Flasz, J. L. Castro, M. MacCoss, D. J. Dixon, R. S. Paton, C. J. Schofield, M. D. Smith and M. C. Willis, Chem. Sci., 2018, 9, 629 DOI: 10.1039/C7SC03891G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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