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Issue 72, 2018
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Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides

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Abstract

We report the synthesis of bipyridyl ligands and these ligands were applied in the chromium-catalyzed enantioselective Nozaki–Hiyama–Kishi allylation of substituted (2-ethoxycarbonyl)benzaldehydes and subsequently lactonized to synthesize phthalides with an optimal enantioselectivity of 99%. This approach was applied to synthesize (S)-cytosporone E at a 71% yield in three steps.

Graphical abstract: Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides

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Supplementary files

Article information


Submitted
21 Nov 2018
Accepted
23 Nov 2018
First published
12 Dec 2018

This article is Open Access

RSC Adv., 2018,8, 41355-41357
Article type
Paper

Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides

S. V. Kumbhar and C. Chen, RSC Adv., 2018, 8, 41355
DOI: 10.1039/C8RA09575B

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    [Original citation] - Published by The Royal Society of Chemistry.

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