Design of a fluorogenic PNA probe capable of simultaneous recognition of 3′-overhang and double-stranded sequences of small interfering RNAs

Takaaki Tanabe; Takaya Sato; Yusuke Sato; Seiichi Nishizawa

doi:10.1039/C8RA08759H

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Design of a fluorogenic PNA probe capable of simultaneous recognition of 3′-overhang and double-stranded sequences of small interfering RNAs†

Takaaki Tanabe,^a Takaya Sato,^a Yusuke Sato

*^a and Seiichi Nishizawa

*^a

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* Corresponding authors

^a Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan
E-mail: satoyuu@m.tohoku.ac.jp, nishi@m.tohoku.ac.jp
Fax: +81-22-795-6549
Tel: +81-22-795-6552

Abstract

We developed a new fluorescent peptide nucleic acid (PNA) probe, COT probe, capable of simultaneous recognition of 3′-overhang and double stranded sequences of target small interfering RNA (siRNA).

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Article information

DOI: https://doi.org/10.1039/C8RA08759H
Article type: Paper
Submitted: 23 Oct 2018
Accepted: 09 Dec 2018
First published: 18 Dec 2018
This article is Open Access

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RSC Adv., 2018,8, 42095-42099

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Design of a fluorogenic PNA probe capable of simultaneous recognition of 3′-overhang and double-stranded sequences of small interfering RNAs

T. Tanabe, T. Sato, Y. Sato and S. Nishizawa, RSC Adv., 2018, 8, 42095 DOI: 10.1039/C8RA08759H

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Design of a fluorogenic PNA probe capable of simultaneous recognition of 3′-overhang and double-stranded sequences of small interfering RNAs†

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Design of a fluorogenic PNA probe capable of simultaneous recognition of 3′-overhang and double-stranded sequences of small interfering RNAs

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