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Issue 72, 2018
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Oligosaccharide synthesis on soluble high-molecular weight pHEMA using a photo-cleavable linker

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Abstract

Oligosaccharide synthesis on organic solvent soluble, high molecular weight poly(2-hydroxyethylmethylacrylate) (pHEMA) is described. The pHEMA-bound oligosaccharide could be recovered after each reaction in 90–95% yield using a precipitation method. The methodology was used to synthesize a model tri-galactoside in 48% overall yield and a trisaccharide from the outer core domain of Pseudomonas aeruginosa lipopolysacchride (LPS) in 39% yield. The use of a photo-cleavable linker is also demonstrated to produce reducing-end protected oligosaccharides.

Graphical abstract: Oligosaccharide synthesis on soluble high-molecular weight pHEMA using a photo-cleavable linker

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Publication details

The article was received on 05 Oct 2018, accepted on 02 Dec 2018 and first published on 12 Dec 2018


Article type: Paper
DOI: 10.1039/C8RA08252A
RSC Adv., 2018,8, 41612-41619
  • Open access: Creative Commons BY license
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    Oligosaccharide synthesis on soluble high-molecular weight pHEMA using a photo-cleavable linker

    A. Vartak, S. Thanna, K. Meyer, M. Dermanelian and S. J. Sucheck, RSC Adv., 2018, 8, 41612
    DOI: 10.1039/C8RA08252A

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