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Issue 70, 2018
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Applications of Friedel–Crafts reactions in total synthesis of natural products

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Abstract

Over the years, Friedel–Crafts (FC) reactions have been acknowledged as the most useful and powerful synthetic tools for the construction of a special kind of carbon–carbon bond involving an aromatic moiety. Its stoichiometric and, more recently, its catalytic procedures have extensively been studied. This reaction in recent years has frequently been used as a key step (steps) in the total synthesis of natural products and targeted complex bioactive molecules. In this review, we try to underscore the applications of intermolecular and intramolecular FC reactions in the total syntheses of natural products and complex molecules, exhibiting diverse biological properties.

Graphical abstract: Applications of Friedel–Crafts reactions in total synthesis of natural products

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Publication details

The article was received on 03 Sep 2018, accepted on 03 Nov 2018 and first published on 03 Dec 2018


Article type: Review Article
DOI: 10.1039/C8RA07325B
RSC Adv., 2018,8, 40061-40163
  • Open access: Creative Commons BY-NC license
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    Applications of Friedel–Crafts reactions in total synthesis of natural products

    M. M. Heravi, V. Zadsirjan, P. Saedi and T. Momeni, RSC Adv., 2018, 8, 40061
    DOI: 10.1039/C8RA07325B

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