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Issue 63, 2018, Issue in Progress
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Structure-dependent antiviral activity of catechol derivatives in pyroligneous acid against the encephalomycarditis virus

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Abstract

The pyrolysis product, wood vinegar (WV), from Japanese larch exhibited strong antiviral activity against the encephalomycarditis virus (EMCV). Catechol, 3-methyl-, 4-methyl-, 4-ethyl-, and 3-methoxycatechol, and 2-methyl-1,4-benzenediol were identified as the major antiviral compounds. The viral inhibition ability of these compounds was affected by the structure and position of the substituent group attached to the aromatic skeleton. The IC50 of catechol was 0.67 mg mL−1 and those of its derivatives were <0.40 mg mL−1. Methyl and ethyl substitution in the para position relative to a hydroxyl group obviously increased the antiviral activities. The mode of antiviral action was investigated by adding catechol derivatives at different times of the viral life cycle. It was found that direct inactivations of EMCV by these compounds were the major pathway for the antiviral activity. The effect of catechol derivatives on the host immune system was studied by quantification of Il6 and Ifnb1 expression levels. Increased Il6 expression levels indicate NF-κB activation by reactive oxygen species from auto-oxidations of catechol derivatives, which is also a possible antiviral route. The present research provides indices for production of potent antiviral agents form lignocellulose biomass.

Graphical abstract: Structure-dependent antiviral activity of catechol derivatives in pyroligneous acid against the encephalomycarditis virus

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Publication details

The article was received on 25 Aug 2018, accepted on 13 Oct 2018 and first published on 22 Oct 2018


Article type: Paper
DOI: 10.1039/C8RA07096B
RSC Adv., 2018,8, 35888-35896
  • Open access: Creative Commons BY license
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    Structure-dependent antiviral activity of catechol derivatives in pyroligneous acid against the encephalomycarditis virus

    R. Li, R. Narita, R. Ouda, C. Kimura, H. Nishimura, M. Yatagai, T. Fujita and T. Watanabe, RSC Adv., 2018, 8, 35888
    DOI: 10.1039/C8RA07096B

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