Issue 57, 2018
From the journal:

RSC Advances

KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines: efficient one-pot synthesis of 1,2,4-triazolo[4,3-a]pyridines†

De-Suo Yang,*a   Juan Wang,a   Peng Gao, ORCID logo *a   Zi-Jing Bai,a   Dong-Zhu Duana  and  Ming-Jin Fan ORCID logo a  

* Corresponding authors

a Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, Shaanxi 721013, P. R. China
E-mail: gaopeng_hx@bjwlxy.edu.cn, yangdesuo@163.com

Abstract

A one-pot approach to substituted 1,2,4-triazolo[4,3-a]pyridines has been developed that is based on a KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines. This transition-metal-free procedure was highly efficient and shows good economical and environmental advantages.

Graphical abstract: KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines: efficient one-pot synthesis of 1,2,4-triazolo[4,3-a]pyridines

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Article information

DOI
https://doi.org/10.1039/C8RA06215C
Article type
Paper
Submitted
23 Jul 2018
Accepted
15 Sep 2018
First published
21 Sep 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 32597-32600

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KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines: efficient one-pot synthesis of 1,2,4-triazolo[4,3-a]pyridines

D. Yang, J. Wang, P. Gao, Z. Bai, D. Duan and M. Fan, RSC Adv., 2018, 8, 32597 DOI: 10.1039/C8RA06215C

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