Issue 62, 2018, Issue in Progress

High-throughput lipidomics reveal mirabilite regulating lipid metabolism as anticancer therapeutics

Abstract

Altered lipid metabolism is an emerging hallmark of cancers. Mirabilite has a therapeutic effect on colorectal cancer (CRC); however, its metabolic mechanism remains unclear. This study aims to explore the potential therapeutic targets of mirabilite protection against colorectal cancer in APCmin/+ mice model. Oral administration of mirabilite was started from the ninth month, while the same dosage of distilled water was given to both the control group and the model group. Based on lipidomics, we collected serum samples of all mice at the 20th week and used a non-targeted method to identify the lipid biomarkers of CRC. Compared with C57BL/6J mice, the metabolic profile of CRC model mice was significantly disturbed, and we identified that 25 lipid-related biomarkers, including linoleic acid, 2-hydroxybutyric acid, 6-deoxocastasterone, hypoxanthine, PC(16:1), PC(18:4), and retinyl acetate, were associated with CRC. According to the abovementioned results, there were six lipid molecules with significant differences that can be used as new targets for handling of CRC through six metabolic pathways, namely, linoleic acid metabolism, retinol metabolism, propanoate metabolism, arachidonic acid metabolism, biosynthesis of unsaturated fatty acids and purine metabolism. Compared with the model group, the metabolic profiles of these disorders tend to recover after treatment. These results indicated that the lipid molecules associated with CRC were regulated by mirabilite. In addition, we identified seven key lipid molecules, of which four had statistical significance. After administration of mirabilite, all disordered metabolic pathways showed different degrees of regulation. In conclusion, high-throughput lipidomics approach revealed mirabilite regulating the altered lipid metabolism as anticancer therapeutics.

Graphical abstract: High-throughput lipidomics reveal mirabilite regulating lipid metabolism as anticancer therapeutics

Supplementary files

Article information

Article type
Paper
Submitted
22 Jul 2018
Accepted
29 Sep 2018
First published
18 Oct 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 35600-35610

High-throughput lipidomics reveal mirabilite regulating lipid metabolism as anticancer therapeutics

H. Zhang, A. Zhang, X. Zhou, H. Sun, X. Wang, L. Liang and X. Wang, RSC Adv., 2018, 8, 35600 DOI: 10.1039/C8RA06190D

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