Issue 55, 2018, Issue in Progress

Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications

Abstract

A series of four bolaamphiphiles with different hydrophilic units has been synthesised. All the amphiphiles were well characterised from their physiochemical data. The aggregation tendency of newly synthesised amphiphiles was studied using fluorescence spectroscopy, dynamic light scattering (DLS), and cryogenic electron microscopy (cryo-TEM). Furthermore, their application as nanocarriers for hydrophobic guests was demonstrated by using two established standards, i.e. the dye Nile red and the drug nimodipine. A cytotoxicity and cellular uptake study has been carried out using A549 cells. Due to the presence of an ester linkage in PEG based bolaamphiphiles, a drug release study was performed in the presence of an immobilized enzyme Novozym-435 (a lipase).

Graphical abstract: Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications

Supplementary files

Article information

Article type
Paper
Submitted
11 Jul 2018
Accepted
27 Aug 2018
First published
12 Sep 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 31777-31782

Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications

Rashmi, A. K. Singh, K. Achazi, B. Schade, C. Böttcher, R. Haag and S. K. Sharma, RSC Adv., 2018, 8, 31777 DOI: 10.1039/C8RA05921G

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