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Issue 53, 2018, Issue in Progress
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Organometallic Ag nanostructures prepared using Hypericum perforatum extract are highly effective against multidrug-resistant bacteria

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Abstract

Hypericum perforatum is a rich source of high-value plant secondary metabolites that have been used in the treatment of various ailments since ancient times. Herein, we report the conversion of bulk Ag+ ions into highly potent organometallic Ag nanostructures (OM-Ag-NS) using H. perforatum extract as a phytochelating agent for the first time. Analysis by X-ray diffraction (XRD) of OM-Ag-NS revealed that they are of a hybrid nature and include pure Ag crystal planes and Ag-organic-complex crystal planes. An investigation by scanning electron microscopy (SEM) of the NS revealed the rough nanocube-like morphology of OM-Ag-NS with an average particle size of 32 nm. Ultra-performance liquid chromatography-diode array detector (UPLC-DAD) and Fourier transform infrared (FTIR) spectroscopy of H. perforatum extract and the residue validated the utilization of phytochelating compounds in the synthesis process of OM-Ag-NS. Thermogravimetric analysis (TGA) supplemented the findings of UPLC-DAD and showed the thermal loss of the organic capping agent around OM-Ag-NS between 300 and 320 °C. NanoDrop-ultraviolet and visible (UV) spectroscopic analysis showed that the tailored bandgap energy of OM-Ag-NS was 2.82 eV. Moreover, compared with chemically stabilized Ag nanostructures (CS-Ag-NS), OM-Ag-NS exhibited promising performance against highly virulent multidrug-resistant Escherichia coli (NDM-1) and Klebsiella pneumoniae (KPC). Our current findings suggest that H. perforatum is a top candidate for tailoring the potential of NS towards various biological activities.

Graphical abstract: Organometallic Ag nanostructures prepared using Hypericum perforatum extract are highly effective against multidrug-resistant bacteria

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Publication details

The article was received on 02 Jul 2018, accepted on 14 Aug 2018 and first published on 29 Aug 2018


Article type: Paper
DOI: 10.1039/C8RA05655B
Citation: RSC Adv., 2018,8, 30562-30572
  • Open access: Creative Commons BY-NC license
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    Organometallic Ag nanostructures prepared using Hypericum perforatum extract are highly effective against multidrug-resistant bacteria

    Q. Maqbool, D. Kruszka, P. Kachlicki and G. Franklin, RSC Adv., 2018, 8, 30562
    DOI: 10.1039/C8RA05655B

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