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Issue 45, 2018, Issue in Progress
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A MOF-based carrier for in situ dopamine delivery

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Abstract

MIL-88A (Fe) MOF crystals were nucleated and grown around a polymer core containing superparamagnetic nanoparticles to assemble a new class of biocompatible particles for magnetophoretic drug delivery of dopamine. The carrier enabled efficient targeted release, dopamine protection from oxidative damage, long-term delivery and improved drug delivery cost-efficiency. After loading, dopamine was stable within the carrier and did not undergo oxidation. Drug release monitoring via spectrofluorimetry revealed a shorter burst effect and higher release efficiency than silica based carriers. The in vitro cytotoxicity at different MOF concentrations and sizes was assessed using PC12 cells as the neuronal cell model. The drug was directly uptaken into the PC12 cells avoiding possible side effects due to oxidation occurring in the extracellular environment.

Graphical abstract: A MOF-based carrier for in situ dopamine delivery

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Publication details

The article was received on 10 Jun 2018, accepted on 05 Jul 2018 and first published on 18 Jul 2018


Article type: Paper
DOI: 10.1039/C8RA04969F
RSC Adv., 2018,8, 25664-25672
  • Open access: Creative Commons BY-NC license
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    A MOF-based carrier for in situ dopamine delivery

    A. Pinna, R. Ricco', R. Migheli, G. Rocchitta, P. A. Serra, P. Falcaro, L. Malfatti and P. Innocenzi, RSC Adv., 2018, 8, 25664
    DOI: 10.1039/C8RA04969F

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