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Issue 49, 2018, Issue in Progress
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Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus Trichoderma harzianum

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Abstract

Two new hydroxyanthraquinones, harzianumnones A (1) and B (2), together with seven known analogs (3–9), were isolated from the soft coral-derived fungus Trichoderma harzianum (XS-20090075). Their chemical structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by ECD calculation and single-crystal X-ray diffraction. Compounds 1 and 2 were identified as a pair of epimers, which are the first example of hydroanthraquinones from T. harzianum. Compounds 7 and 8 exhibited cytotoxicity against hepatoma cell line HepG2 with IC50 values of 2.10 and 9.39 μM, respectively. Compound 7 was still found to show cytotoxicity against cervical cancer cell line HeLa with an IC50 value of 8.59 μM.

Graphical abstract: Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus Trichoderma harzianum

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Supplementary files

Article information


Submitted
07 Jun 2018
Accepted
20 Jul 2018
First published
02 Aug 2018

This article is Open Access

RSC Adv., 2018,8, 27596-27601
Article type
Paper

Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus Trichoderma harzianum

T. Shi, X. Hou, Z. Li, F. Cao, Y. Zhang, J. Yu, D. Zhao, C. Shao and C. Wang, RSC Adv., 2018, 8, 27596
DOI: 10.1039/C8RA04865G

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