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Issue 47, 2018, Issue in Progress
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Energetic differences between non-domain-swapped and domain-swapped chain connectivities in the K2P potassium channel TRAAK

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Abstract

Two-pore domain (K2P) channels are twofold symmetric K+ channels which control cell excitability by enabling the leak of potassium ions from cells in response to physicochemical stimuli. Crystallization of K2P channels revealed the presence of several structural features, which include an external cap. In the available crystallographic structures, the cap is present as non-domain-swapped (NDS) and domain-swapped (DS) chain conformations, where DS chain conformation exchanges two opposing outer helices 180° around the channel. In this work, energy differences between the residues located at the highest point of the cap in NDS and DS conformations were evaluated for TRAAK, a K2P channel that was crystallized in both conformations. Results indicated a preference for DS conformation, but this result is not extensible to TASK K2P channels.

Graphical abstract: Energetic differences between non-domain-swapped and domain-swapped chain connectivities in the K2P potassium channel TRAAK

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Publication details

The article was received on 16 May 2018, accepted on 19 Jul 2018 and first published on 25 Jul 2018


Article type: Paper
DOI: 10.1039/C8RA04159H
RSC Adv., 2018,8, 26610-26618
  • Open access: Creative Commons BY license
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    Energetic differences between non-domain-swapped and domain-swapped chain connectivities in the K2P potassium channel TRAAK

    C. Navarro-Retamal and J. Caballero, RSC Adv., 2018, 8, 26610
    DOI: 10.1039/C8RA04159H

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