Issue 48, 2018, Issue in Progress

Stratum corneum lipid liposomes for investigating skin penetration enhancer effects

Abstract

Knowledge of the mechanism of action of skin penetration enhancers is essential to formulators for optimizing formulations and to maximize the efficacy of enhancers. To obtain information about the effects of penetration enhancers as a fast initial screening, investigations have been performed to identify possible correlations of the biological effectiveness of penetration enhancers with their interaction with a well-defined model system consisting of skin mimic lipid bilayers, as determined by calcein release experiments using stratum corneum lipid liposomes (SCLLs). We aimed to investigate the enhancing effects of different concentrations of two chemical penetration enhancers, Kolliphor RH40 and Transcutol on SCLLs. The results obtained by SCLL-based techniques were compared with conventional ex vivo penetration studies in case of Kolliphor RH40 to evaluate the potential of SCLLs as an alternative tool for screening various types and concentrations of penetration enhancers. As a result, calcein leakage assay performed with SCLL was considered to be a good model for the skin penetration enhancing effect. This method could be used as a time-saving and sensitive alternative in vitro screening technique in the early stage of the development of dermal formulations.

Graphical abstract: Stratum corneum lipid liposomes for investigating skin penetration enhancer effects

Article information

Article type
Paper
Submitted
15 May 2018
Accepted
22 Jul 2018
First published
02 Aug 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 27464-27469

Stratum corneum lipid liposomes for investigating skin penetration enhancer effects

M. Bakonyi, A. Gácsi, S. Berkó, A. Kovács and E. Csányi, RSC Adv., 2018, 8, 27464 DOI: 10.1039/C8RA04129F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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