Modulating effect of selected pharmaceuticals on bone in female rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Abstract

This paper discusses the problems connected with the influence of TCDD on the mechanical properties and structure of the bone tissue in female rats treated with the dioxin. Moreover an analysis of the protective role of tocopherol, acetylsalicylic acid, dexamethazone and levamisol was performed. Rat tibiae were assessed by mechanical testing, and histological and trace element analysis. It was proved that TCDD has negative effect on bone mechanical properties, histological microstructure and trace element content. The results indicate that usage of both steroid and non-steroid anti-inflammatory medicaments, along with tocopherol and levamisol, modulating their activity, can reduce the negative effect of dioxin activity on the bone tissue of female rats intoxicated with TCDD.