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Issue 37, 2018, Issue in Progress
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Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing

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Abstract

Recently, it has been shown that the efficiency of antitumoral drugs can be enhanced when combined with therapeutic siRNAs. In the present study, an original platform based on polydiacetylenic micelles containing a cationic head group able to efficiently deliver a small interfering RNA (siRNA) targeting the PLK-1 gene while offering a hydrophobic environment for encapsulation of lipophilic drugs such as camptothecin is developed. We demonstrate that the co-delivery of these two agents with our micellar system results in a synergistic tumor cell killing of cervical and breast cancer cell lines in vitro. The combined drugs are active in a subcutaneous in vivo cancer model. Altogether, the results show that our nanometric micellar delivery system can be used for the development of new drug–siRNA combo-therapies.

Graphical abstract: Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing

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Publication details

The article was received on 19 Apr 2018, accepted on 28 May 2018 and first published on 06 Jun 2018


Article type: Paper
DOI: 10.1039/C8RA03375G
Citation: RSC Adv., 2018,8, 20758-20763
  • Open access: Creative Commons BY-NC license
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    Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing

    M. Ripoll, M. Pierdant, P. Neuberg, D. Bagnard, A. Wagner, A. Kichler and J. Remy, RSC Adv., 2018, 8, 20758
    DOI: 10.1039/C8RA03375G

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