Issue 42, 2018, Issue in Progress
From the journal:

RSC Advances

On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth

Heloiza F. O. Silva,a   Rayane P. de Lima,a   Fernanda S. L. da Costa,a   Edgar P. Moraes,a   Maria C. N. Melo,b   Celso Sant’Anna,c   Mateus Eugênioc  and  Luiz H. S. Gasparotto*a  

* Corresponding authors

a Biological Chemistry and Chemometrics Research Group, Institute of Chemistry, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brasil
E-mail: lhgasparotto@ufrnet.br
Tel: +55 84 33422323

b Laboratory of Medical Bacteriology, Center of Biosciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brasil

c Laboratory of Biotechnology – Labio, National Institute of Metrology, Quality and Technology – Inmetro, Duque de Caxias 25250-020, RJ, Brazil

Abstract

In a previous paper (RSC Adv., 2015, 5, 66886–66893), we showed that the combination of silver nanoparticles (NanoAg) with doxycycline (DO) culminated in an increased bactericidal activity towards E. coli. Herein we further investigated the metabolic changes that occurred on Staphylococcus aureus upon exposure to NanoAg with the help of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) coupled with multivariate data analysis. It has been discovered that the combination of DO with NanoAg produced metabolic changes in S. aureus that were not simply the overlap of the treatments with DO and NanoAg separately. Our results suggest that DO and NanoAg act synergistically to impede protein synthesis by the bacteria.

Graphical abstract: On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth

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Article information

DOI
https://doi.org/10.1039/C8RA02176G
Article type
Paper
Submitted
12 Mar 2018
Accepted
21 Jun 2018
First published
28 Jun 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 23578-23584

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On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth

H. F. O. Silva, R. P. de Lima, F. S. L. da Costa, E. P. Moraes, M. C. N. Melo, C. Sant’Anna, M. Eugênio and L. H. S. Gasparotto, RSC Adv., 2018, 8, 23578 DOI: 10.1039/C8RA02176G

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