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Issue 26, 2018, Issue in Progress
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Molecularly imprinted ‘traps’ for sulfonylureas prepared using polymerisable ion pairs

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Abstract

A novel approach towards recognition of sulfonylureas based on a polymerisable ion pair is presented. A solution association constant >105 M−1 between the model target glibenclamide and 4-vinylbenzyltrimethylammonium methacrylate is measured, and the formation of 1 : 1 complexes verified. Subsequently prepared stoichiometrically imprinted polymers exhibit exceptionally high affinity and binding capacity for glibenclamide, owing to synergistic binding of both the neutral and deprotonated form of the drug by the ion pair monomer. The polymers are applied to the selective extraction of glibenclamide from blood serum samples, achieving recoveries of up to 98% and demonstrating excellent long-term stability, negating the need for regular sorbent regeneration.

Graphical abstract: Molecularly imprinted ‘traps’ for sulfonylureas prepared using polymerisable ion pairs

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Supplementary files

Article information


Submitted
05 Feb 2018
Accepted
11 Apr 2018
First published
17 Apr 2018

This article is Open Access

RSC Adv., 2018,8, 14212-14220
Article type
Paper

Molecularly imprinted ‘traps’ for sulfonylureas prepared using polymerisable ion pairs

F. Pessagno, A. N. Hasanah and P. Manesiotis, RSC Adv., 2018, 8, 14212
DOI: 10.1039/C8RA01135D

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