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Issue 23, 2018, Issue in Progress
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Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

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Abstract

We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations.

Graphical abstract: Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

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Supplementary files

Article information


Submitted
01 Feb 2018
Accepted
19 Mar 2018
First published
03 Apr 2018

This article is Open Access

RSC Adv., 2018,8, 12614-12618
Article type
Paper

Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

L. Du, J. Shen, Z. Dong, N. Zhou, B. Cheng, Z. Ou and X. Luo, RSC Adv., 2018, 8, 12614
DOI: 10.1039/C8RA01030G

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