Issue 14, 2018, Issue in Progress

Efficient synthesis of ether phosphonates using trichloroacetimidate and acetate coupling methods

Abstract

A series of ether phosphonates have been prepared by trichloroacetimidate and acetate coupling methods. Trichloroacetimidates or acetates were treated with primary and secondary alcohols as O-nucleophiles in the presence of catalytic TMSOTf to afford 21 examples of diethyl alkyloxy(substitutedphenyl)methyl phosphonates via C–O bond formation in 55–90% yields and short reaction time.

Graphical abstract: Efficient synthesis of ether phosphonates using trichloroacetimidate and acetate coupling methods

Article information

Article type
Paper
Submitted
23 Jan 2018
Accepted
09 Feb 2018
First published
15 Feb 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 7385-7395

Efficient synthesis of ether phosphonates using trichloroacetimidate and acetate coupling methods

Walid. Fathalla, Ibrahim. A. I. Ali and Pavel. Pazdera, RSC Adv., 2018, 8, 7385 DOI: 10.1039/C8RA00702K

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