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Issue 20, 2018, Issue in Progress
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Shape and structure controlling of calcium oxalate crystals by a combination of additives in the process of biomineralization

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Abstract

The origin of complex hierarchical superstructures of biomaterials and their unique self-assembly mechanisms of formation are important in biological systems and have attracted considerable attention. In the present study, we investigated the morphological changes of calcium oxalate (CaOx) crystals induced by additives including chiral aspartic acid, sodium citrate, Mg2+, casein and combinations of these molecules. The morphology and structure of CaOx were identified with the use of various techniques. The morphogenesis of CaOx crystals were significantly affected by chiral aspartic acid, sodium citrate or Mg2+. However, they only formed calcium oxalate monohydrate (COM). It was observed that the chiral aspartic acid, sodium citrate and casein adhered to the surface of the crystals. The adherence of Mg2+ to crystals was not evident. Casein significantly affected the formation of COM and calcium oxalate dihydrate (COD). The ratio of different CaOx crystal forms is associated with the casein concentration. In combination with Mg2+ or citrate ions, casein showed improved formation of COD. The present study mimics biomineralization with a simple chemical approach and provides insight into the complicated system of CaOx biomineralization as well as facilitates the understanding of urinary stone treatment.

Graphical abstract: Shape and structure controlling of calcium oxalate crystals by a combination of additives in the process of biomineralization

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Supplementary files

Article information


Submitted
22 Jan 2018
Accepted
05 Mar 2018
First published
20 Mar 2018

This article is Open Access

RSC Adv., 2018,8, 11014-11020
Article type
Paper

Shape and structure controlling of calcium oxalate crystals by a combination of additives in the process of biomineralization

N. Liu, H. Xie, H. Ping, L. Wang, Z. Liu, F. Tao, J. Guo and B. Su, RSC Adv., 2018, 8, 11014
DOI: 10.1039/C8RA00661J

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