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Issue 29, 2018, Issue in Progress
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ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues

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Abstract

An eco-friendly acetylcholine iodide–ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2-b]isoquinoline analogues. The effects of the synthesized compounds on the osteoblast differentiation of hBMSC-TERT cell lines were investigated and promising results were observed with significant IC50 values. In addition, molecular modeling simulations were also performed with the 3D structure of BMP-2 to reveal binding interactions and orientations of highly potent spiropyrrolo[1,2-b]isoquinoline analogues.

Graphical abstract: ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues

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Publication details

The article was received on 22 Jan 2018, accepted on 13 Apr 2018 and first published on 02 May 2018


Article type: Paper
DOI: 10.1039/C8RA00646F
RSC Adv., 2018,8, 16303-16313
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    ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues

    G. Periyasami, N. Arumugam, M. Rahaman, R. S. Kumar, M. Manikandan, M. A. Alfayez, D. Premnath and A. Aldalbahi, RSC Adv., 2018, 8, 16303
    DOI: 10.1039/C8RA00646F

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