Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 17, 2018, Issue in Progress
Previous Article Next Article

l-Menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa B, p38 MAPK and Nrf2 signalling pathways

Author affiliations

Abstract

L-Menthol is the main ingredient of peppermint which affects various pharmacological effects such as anti-inflammation and anti-oxidative activity. In this study, we aimed to evaluate the potential effects of L-menthol on cigarette smoke extract (CSE) induced lung injury in rats. Morphology assessment results revealed that administration with L-menthol (5, 10 or 20 mg kg−1 d−1) significantly alleviated CSE-induced lung injury. Besides, L-menthol significantly reduced the inflammatory response by suppressing the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) via downregulating nuclear factor kappa B (NF-κB) and p38 MAPK pathways. Meanwhile, L-menthol decreased the levels of oxidative stress markers including malondialdehyde (MDA) and myeloperoxidase (MPO) whereas it increased the amount of glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) through activation of the Nrf2 pathway. Furthermore, the expression of MMP-9 and TIMP-1 in lungs was reduced after treatment with L-menthol, and this indicated that L-menthol might have a potential effect on airway remodeling. Moreover, immunohistochemistry analyses indicated that L-menthol could suppress the infiltration of CD4+ and CD8+ T cells in lung tissues and this was probably due to the immune regulation activity of L-menthol. Taken together, our findings support that L-menthol might be a potential candidate for the treatment of CSE-induced lung injury in rats.

Graphical abstract: l-Menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa B, p38 MAPK and Nrf2 signalling pathways

Back to tab navigation

Article information


Submitted
06 Jan 2018
Accepted
27 Feb 2018
First published
05 Mar 2018

This article is Open Access

RSC Adv., 2018,8, 9353-9363
Article type
Paper

L-Menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa B, p38 MAPK and Nrf2 signalling pathways

Y. Liu, A. Li, X. Feng, X. Jiang, X. Sun, W. Huang, X. Zhu and Z. Zhao, RSC Adv., 2018, 8, 9353
DOI: 10.1039/C8RA00160J

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements